Between Proteus, orcad, Mentor Graphics, Tina, Altium, etc.

I'm testing, using an oscillator LM339 to oscillate at a frequency 220KHZ

Why not try LT Spice ? It's probably industry standard these days, and there are plenty of places where you can download free model for LM330 http://ltwiki.org/?title=Components_...y_and_Circuits or https://github.com/evenator/LTSpice-.../sub/LM339.sub